A chemically induced attenuated strain of Candida albicans generates robust protective immune responses and prevents systemic candidiasis development

Despite current antifungal therapy, invasive candidiasis causes >40% mortality in immunocompromised individuals. Therefore, developing an antifungal vaccine is a priority. Here, we could for the first time successfully attenuate the virulence of Candida albicans by treating it with a fungista...

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Bibliographic Details
Published in:eLife
Main Authors: Swagata Bose, Satya Ranjan Sahu, Abinash Dutta, Narottam Acharya
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-05-01
Subjects:
Candida
Candida albicans
candidiasis
attenuation
Whole-cell vaccine
Cytokines
Online Access:https://elifesciences.org/articles/93760

Internet

https://elifesciences.org/articles/93760

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