Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis

Nonribosomal lipopeptides contain an acyl chain important for bioactivity, but its incorporation into the peptidyl backbone, mediated by the starter condensation (Cs) domain of nonribosomal peptide synthases, is not fully understood. Here, the authors show that acyl chains of different lengths can b...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Lin Zhong, Xiaotong Diao, Na Zhang, Fengwei Li, Haibo Zhou, Hanna Chen, Xianping Bai, Xintong Ren, Youming Zhang, Dalei Wu, Xiaoying Bian
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-01-01
Online Access:	https://doi.org/10.1038/s41467-020-20548-8