Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion

Summary: Host and fungal pathogens compete for metal ion acquisition during infectious processes, but molecular mechanisms remain largely unknown. Here, we show that type I interferons (IFNs-I) dysregulate zinc homeostasis in macrophages, which employ metallothionein-mediated zinc intoxication of pa...

Full description

Bibliographic Details

Published in:	iScience
Main Authors:	Michael Riedelberger, Philipp Penninger, Michael Tscherner, Bernhard Hadriga, Carina Brunnhofer, Sabrina Jenull, Anton Stoiber, Christelle Bourgeois, Andriy Petryshyn, Walter Glaser, Andreas Limbeck, Michael A. Lynes, Gernot Schabbauer, Guenter Weiss, Karl Kuchler
Format:	Article
Language:	English
Published:	Elsevier 2020-05-01
Subjects:	Immunology Immune Respons Immune Response
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589004220303060