Characterization of In Vitro 3D Cell Model Developed from Human Hepatocellular Carcinoma (HepG2) Cell Line

In genetic toxicology, there is a trend against the increased use of in vivo models as highlighted by the 3R strategy, thus encouraging the development and implementation of alternative models. Two-dimensional (2D) hepatic cell models, which are generally used for studying the adverse effects of che...

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Bibliographic Details
Published in:Cells
Main Authors: Martina Štampar, Barbara Breznik, Metka Filipič, Bojana Žegura
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Subjects:
3D cell model
HepG2
cell proliferation
cell cycle
gene expression
Online Access:https://www.mdpi.com/2073-4409/9/12/2557

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