Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex

Herein, we reported on the synthesis of a novel Pt(II) neutral complex having as ligand the nucleoside tubercidin, a potent anti-tumor agent extracted from the bacterium <i>Streptomyces Tubercidicus</i>. In detail, the chelation of the metal by a diamine linker installed at C6 purine pos...

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Bibliographic Details

Published in:	Pharmaceutics
Main Authors:	Stefano D’Errico, Andrea Patrizia Falanga, Domenica Capasso, Sonia Di Gaetano, Maria Marzano, Monica Terracciano, Giovanni Nicola Roviello, Gennaro Piccialli, Giorgia Oliviero, Nicola Borbone
Format:	Article
Language:	English
Published:	MDPI AG 2020-07-01
Subjects:	tubercidin cisplatin platinum complexes nucleosides cancer CD spectroscopy
Online Access:	https://www.mdpi.com/1999-4923/12/7/627