GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis

IntroductionInhibition of STAT5 was recently reported to reduce murine atherosclerosis. However, the role of STAT5 isoforms, and more in particular STAT5A in macrophages in the context of human atherosclerosis remains unknown.Methods and resultsHere, we demonstrate reciprocal expression regulation o...

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Bibliographic Details
Published in:Frontiers in Immunology
Main Authors: Jan Nagenborg, Han Jin, Adele V. Ruder, Lieve Temmerman, Barend Mees, Casper Schalkwijk, Daniel Müller-Klieser, Thorsten Berg, Pieter Goossens, Marjo M. P. C. Donners, Erik A. L. Biessen
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Subjects:
STAT5A
STAT5B
GM-CSF
macrophage
atherosclerosis
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165306/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165306/full

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