Effect of glucose depletion and fructose administration during chondrogenic commitment in human bone marrow-derived stem cells

Abstract Background Bone marrow mesenchymal stromal cells (BMSCs) are promising for therapeutic use in cartilage repair, because of their capacity to differentiate into chondrocytes. Often, in vitro differentiation protocols employ the use of high amount of glucose, which does not reflect cartilage...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Daniele Zuncheddu, Elena Della Bella, Dalila Petta, Cecilia Bärtschi, Sonja Häckel, Moritz C. Deml, Martin J. Stoddart, Sibylle Grad, Valentina Basoli
Format:	Article
Language:	English
Published:	BMC 2022-12-01
Subjects:	Human mesenchymal stem cells Differentiation Chondrogenesis Cartilage Fructose Glucose
Online Access:	https://doi.org/10.1186/s13287-022-03214-2