Chromatin’s Influence on Pre-Replication Complex Assembly and Function

In all eukaryotes, the initiation of DNA replication requires a stepwise assembly of factors onto the origins of DNA replication. This is pioneered by the Origin Recognition Complex, which recruits Cdc6. Together, they bring Cdt1, which shepherds MCM2-7 to form the OCCM complex. Sequentially, a seco...

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Bibliographic Details

Published in:	Biology
Main Authors:	Hina Ahmad, Neha Chetlangia, Supriya G. Prasanth
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Subjects:	DNA replication chromatin ORC pre-replication complex (pre-RC) epigenetics polycomb (Pc)
Online Access:	https://www.mdpi.com/2079-7737/13/3/152