Assessment of immune cell profiles among post-menopausal women in the Women’s Health Initiative using DNA methylation-based methods

Abstract Background Over the past decade, DNA methylation (DNAm)-based deconvolution methods that leverage cell-specific DNAm markers of immune cell types have been developed to provide accurate estimates of the proportions of leukocytes in peripheral blood. Immune cell phenotyping using DNAm marker...

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Bibliographic Details

Published in:	Clinical Epigenetics
Main Authors:	Emily Nissen, Alexander Reiner, Simin Liu, Robert B. Wallace, Annette M. Molinaro, Lucas A. Salas, Brock C. Christensen, John K. Wiencke, Devin C. Koestler, Karl T. Kelsey
Format:	Article
Language:	English
Published:	BMC 2023-04-01
Subjects:	Population WHI Immune cell reference limits Reference values Immune cell phenotyping Methylation cytometry
Online Access:	https://doi.org/10.1186/s13148-023-01488-8