Chronic myeloid leukemia: the paradigm of targeting oncogenic tyrosine kinase signaling and counteracting resistance for successful cancer therapy

Abstract Deregulated activity of BCR-ABL1, a nonreceptor tyrosine kinase encoded by the fusion gene resulting from the t(9;22)(q34;q11) chromosomal translocation, is thought to be the driver event responsible for initiation and maintenance of chronic myeloid leukemia (CML). BCR-ABL1 was one of the f...

Full description

Bibliographic Details

Published in:	Molecular Cancer
Main Authors:	Simona Soverini, Manuela Mancini, Luana Bavaro, Michele Cavo, Giovanni Martinelli
Format:	Article
Language:	English
Published:	BMC 2018-02-01
Subjects:	BCR-ABL1 Tyrosine kinase Tyrosine kinase inhibitors Resistance
Online Access:	http://link.springer.com/article/10.1186/s12943-018-0780-6