MAL2 reprograms lipid metabolism in intrahepatic cholangiocarcinoma via EGFR/SREBP-1 pathway based on single-cell RNA sequencing

Abstract Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive cancer characterized by a poor prognosis and resistance to chemotherapy. In this study, utilizing scRNA-seq, we discovered that the tetra-transmembrane protein mal, T cell differentiation protein 2 (MAL2), exhibited specific enric...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Tian Huang, Hengsong Cao, Chuan Liu, Xiaohu Sun, Shipeng Dai, Li Liu, Yuliang Wang, Cheng Guo, Xuehao Wang, Yun Gao, Weiwei Tang, Yongxiang Xia
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-06-01
Online Access:	https://doi.org/10.1038/s41419-024-06775-7