Genomic variants exclusively identified in children with birth defects and concurrent malignant tumors predispose to cancer development

Abstract Children with birth defects (BD) express distinct clinical features that often have various medical consequences, one of which is predisposition to the development of cancers. Identification of the underlying genetic mechanisms related to the development of cancer in BD patients would allow...

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Bibliographic Details

Published in:	Molecular Cancer
Main Authors:	Yichuan Liu, Hui-Qi Qu, Xiao Chang, Frank D Mentch, Haijun Qiu, Xiang Wang, Amir Hossein Saeidian, Deborah Watson, Joseph Glessner, Hakon Hakonarson
Format:	Article
Language:	English
Published:	BMC 2023-08-01
Subjects:	Pediatric cancer development Birth defects Sequencing
Online Access:	https://doi.org/10.1186/s12943-023-01828-5