c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity

Summary: Metabolic syndrome is associated with obesity, insulin resistance, and the risk of cancer. We tested whether oncogenic transcription factor c-JUN metabolically reprogrammed cells to induce obesity and cancer by reduction of glucose uptake, with promotion of the stemness phenotype leading to...

Full description

Bibliographic Details

Published in:	iScience
Main Authors:	Raphael Serna, Ambika Ramrakhiani, Juan Carlos Hernandez, Chia-Lin Chen, Chad Nakagawa, Tatsuya Machida, Ratna B. Ray, Xiaohang Zhan, Stanley M. Tahara, Keigo Machida
Format:	Article
Language:	English
Published:	Elsevier 2022-06-01
Subjects:	Biological sciences Molecular biology Endocrinology Diabetology Cell biology Cancer
Online Access:	http://www.sciencedirect.com/science/article/pii/S258900422200596X