Hereditary diffuse gastric and lobular breast cancer syndrome associated with germline CDH1 variants: focus on lobular breast cancer

Abstract Background Hereditary lobular breast cancer (HLBC) is a distinct subset of hereditary breast cancer primarily associated with germline pathogenic variants in the CDH1 gene, which encodes E-cadherin, a crucial protein in cell adhesion. Loss of E-cadherin disrupts tissue architecture, contrib...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Journal of Cancer Research and Clinical Oncology
المؤلفون الرئيسيون: Giovanni Corso, Francesca Magnoni, Giorgio Bogani, Paolo Veronesi, Viviana Galimberti, Adriana Albini
التنسيق: مقال
اللغة:الإنجليزية
منشور في: Springer 2025-05-01
الموضوعات:
Hereditary lobular breast cancer
CDH1 gene
Genetic screening
E-cadherin
IGCLC guidelines
الوصول للمادة أونلاين:https://doi.org/10.1007/s00432-025-06222-w

الانترنت

https://doi.org/10.1007/s00432-025-06222-w

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