The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2.

Sequencing of primary colorectal tumors has identified a gene fusion in approximately 3% of colorectal cancer patients of the VTI1A and TCF7L2 genes, encoding a VTI1A-TCF4 fusion protein containing a truncated TCF4. As dysregulation of the Wnt signaling pathway is associated with colorectal cancer d...

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出版年:	PLoS ONE
主要な著者:	Johanne Davidsen, Sylvester Larsen, Mehmet Coskun, Ismail Gögenur, Katja Dahlgaard, Eric Paul Bennett, Jesper Thorvald Troelsen
フォーマット:	論文
言語:	英語
出版事項:	Public Library of Science (PLoS) 2018-01-01
オンライン･アクセス:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0200215&type=printable