High-resolution accurate mass- mass spectrometry based- untargeted metabolomics: Reproducibility and detection power across data-dependent acquisition, data-independent acquisition, and AcquireX

Untargeted metabolomics aims at the unbiased metabolic profiling and biomarker discovery but requires methods with high sensitivity and reproducibility. Here, we compare three acquisition modes—Data-Dependent Acquisition (DDA), Data-Independent Acquisition (DIA), and AcquireX —to evaluate performanc...

Full description

Bibliographic Details

Published in:	Computational and Structural Biotechnology Journal
Main Authors:	Hanane El Boudlali, Laura Lehmicke, Uta Ceglarek
Format:	Article
Language:	English
Published:	Elsevier 2025-01-01
Subjects:	AcquireX DDA DIA detection power reproducibility
Online Access:	http://www.sciencedirect.com/science/article/pii/S2001037025002090