Multi-functions of exonuclease 1 in DNA damage response and cancer susceptibility

Exonuclease 1 (EXO1) can catalyze nucleotide chain excision with its conserved N-terminal domain of 5′ to 3′ exonuclease activity, enabling it to influence diverse biological processes facing the challenges of genotoxic environmental factors such as ionizing radiation. This nuclease activity enables...

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Bibliographic Details

Published in:	Radiation Medicine and Protection
Main Authors:	Shuang Yan, Shanshan Gao, Pingkun Zhou
Format:	Article
Language:	English
Published:	Elsevier 2021-12-01
Subjects:	Exonuclease 1(EXO1) Radiotherapy DNA double-strand break (DSB) DNA recombination Cancer susceptibility DNA end resection
Online Access:	http://www.sciencedirect.com/science/article/pii/S2666555721000551