Tumor-draining lymph nodes respond to immune checkpoint inhibition and orchestrate tumor immune remodeling

Abstract Background Immune checkpoint inhibitors have traditionally been understood to exert their effects primarily within the tumor microenvironment, particularly targeting CD8 + T cells. However, recent studies have highlighted a pivotal role of tumor-draining lymph nodes in mediating responses t...

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Bibliographic Details

Published in:	Cancer Immunology, Immunotherapy
Main Authors:	Jinzhu Zhang, Jian Ma, Yaru Niu, Jialiang Liu, Zhexue Wang, Jinyuan Guo, Yongsheng Meng, Ruifang Sun, Zhen Zhang, Haiyi Liu, Juan Xu, Likun Zan, Xu Guan, Xishan Wang
Format:	Article
Language:	English
Published:	Springer 2025-10-01
Subjects:	Immune checkpoint inhibition Colorectal cancer Tumor-draining lymph nodes
Online Access:	https://doi.org/10.1007/s00262-025-04187-w