Alteration of the Antitumor Immune Response by Cancer-Associated Fibroblasts

Among cells present in the tumor microenvironment, activated fibroblasts termed cancer-associated fibroblasts (CAFs), play a critical role in the complex process of tumor-stroma interaction. CAFs, one of the prominent stromal cell populations in most types of human carcinomas, have been involved in...

Full description

Bibliographic Details
Published in:	Frontiers in Immunology
Main Authors:	Linda Ziani, Salem Chouaib, Jerome Thiery
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-03-01
Subjects:	cancer tumor microenvironment cancer-associated fibroblasts immune suppression immunotherapy
Online Access:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00414/full

Similar Items

Modulation of the antitumor immune response by cancer-associated fibroblasts: mechanisms and targeting strategies to hamper their immunosuppressive functions
by: Jerome Thiery
Published: (2022-10-01)

Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition
by: Agnete S. T. Engelsen, et al.
Published: (2022-04-01)

Immune checkpoint inhibitors as mediators for immunosuppression by cancer-associated fibroblasts: A comprehensive review
by: Fatemeh Eskandari-Malayeri, et al.
Published: (2022-10-01)

Paracrine signaling in cancer-associated fibroblasts: central regulators of the tumor immune microenvironment
by: Ye Li, et al.
Published: (2025-06-01)

Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment
by: Etienne D. Foucher, et al.
Published: (2018-05-01)

Metabolic reprogramming and crosstalk of cancer-related fibroblasts and immune cells in the tumor microenvironment
by: Yifei Zhu, et al.
Published: (2022-08-01)

Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment
by: Martin eAugsten
Published: (2014-03-01)

Overcoming cancer treatment resistance: Unraveling the role of cancer-associated fibroblasts
by: Xiaoyuan Wang, et al.
Published: (2025-06-01)

Hydrogen Therapy Reverses Cancer‐Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti‐Tumor Immunity
by: Xiaoyan Meng, et al.
Published: (2024-07-01)

Editorial: Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy
by: Salem Chouaib, et al.
Published: (2020-05-01)

Machine learning identifies characteristics molecules of cancer associated fibroblasts significantly correlated with the prognosis, immunotherapy response and immune microenvironment in lung adenocarcinoma
by: Qian Wang, et al.
Published: (2022-11-01)

Cancer associated fibroblasts and metabolic reprogramming: unraveling the intricate crosstalk in tumor evolution
by: Fusheng Zhang, et al.
Published: (2024-09-01)

Dissecting the role of cancer‐associated fibroblast‐derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single‐cell transcriptomic study
by: Shaoquan Zheng, et al.
Published: (2023-02-01)

Development and validation of cancer-associated fibroblasts-related gene landscape in prognosis and immune microenvironment of bladder cancer
by: Meng Zhang, et al.
Published: (2023-06-01)

Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts
by: Zhongsong Zhang, et al.
Published: (2025-01-01)

Cancer-associated fibroblast-mediated immune evasion: molecular mechanisms of stromal-immune crosstalk in the tumor microenvironment
by: Junling Luo, et al.
Published: (2025-08-01)

Current Strategies to Target Tumor-Associated-Macrophages to Improve Anti-Tumor Immune Responses
by: Clément Anfray, et al.
Published: (2019-12-01)

Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy
by: Zhang Z, et al.
Published: (2025-01-01)

Cancer‑associated fibroblasts: a pivotal regulator of tumor microenvironment in the context of radiotherapy
by: Linhui Zheng, et al.
Published: (2025-03-01)

Fibroblasts Influence the Efficacy, Resistance, and Future Use of Vaccines and Immunotherapy in Cancer Treatment
by: Bailee H. Sliker, et al.
Published: (2021-06-01)

Recent Advances in Lung Cancer Immunotherapy: Input of T-Cell Epitopes Associated With Impaired Peptide Processing
by: Marine Leclerc, et al.
Published: (2019-07-01)

Cancer-Associated Fibroblast Heterogeneity, Activation and Function: Implications for Prostate Cancer
by: Jasmine S. Owen, et al.
Published: (2022-12-01)

Pan-cancer analyses and molecular subtypes based on the cancer-associated fibroblast landscape and tumor microenvironment infiltration characterization reveal clinical outcome and immunotherapy response in epithelial ovarian cancer
by: Ruoyao Zou, et al.
Published: (2022-08-01)

Unraveling the role of cancer-associated fibroblasts in B cell lymphoma
by: Prithviraj Mukherjee, et al.
Published: (2024-11-01)

Comprehensive analyses of the cancer-associated fibroblast subtypes and their score system for prediction of outcomes and immunosuppressive microenvironment in prostate cancer
by: Ze Gao, et al.
Published: (2024-04-01)

Cancer-associated fibroblasts in osteosarcoma: key players in immune escape and targeted therapy
by: Junjie Fan, et al.
Published: (2025-09-01)

Cancer-associated fibroblasts in ovarian cancer: research progress
by: Yuance Xu, et al.
Published: (2025-03-01)

Editorial: Role of fibroblast in cancer
by: Xuezhen Zeng, et al.
Published: (2025-02-01)

Effect of activating cancer-associated fibroblasts biomarker TNC on immune cell infiltration and prognosis in breast cancer
by: Ting Huang, et al.
Published: (2023-12-01)

Cancer-associated fibroblasts in radiotherapy: challenges and new opportunities
by: Zhanhuai Wang, et al.
Published: (2019-05-01)

Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy
by: Els Lebegge, et al.
Published: (2020-07-01)

Research Progress on Therapeutic Targeting of Cancer-Associated Fibroblasts to Tackle Treatment-Resistant NSCLC
by: Chenxin Li, et al.
Published: (2022-11-01)

Improving Cancer Immunotherapy by Targeting the Hypoxic Tumor Microenvironment: New Opportunities and Challenges
by: Muhammad Zaeem Noman, et al.
Published: (2019-09-01)

Editorial: Immune modulation in tumor microenvironment: New perspectives for cancer immunotherapy
by: Zimu Deng, et al.
Published: (2023-01-01)

Integration of single-cell RNA-seq and bulk RNA-seq data to construct and validate a cancer-associated fibroblast-related prognostic signature for patients with ovarian cancer
by: Liang Shen, et al.
Published: (2024-04-01)

Exploration of Immune Tolerance and Treatment for Esophageal Cancer
by: XING Siyuan, et al.
Published: (2023-12-01)

Cancer-Associated Fibroblasts and Extracellular Matrix: Therapeutical Strategies for Modulating the Cholangiocarcinoma Microenvironment
by: Mirko Minini, et al.
Published: (2023-04-01)

The implications of oncolytic viruses targeting fibroblasts in enhancing the antitumoural immune response
by: Ibrahem Al-Obaidi, et al.
Published: (2024-10-01)

Multifaceted Role of the Transforming Growth Factor β on Effector T Cells and the Implication for CAR-T Cell Therapy
by: Apolline de Folmont, et al.
Published: (2021-06-01)

Rethinking the Roles of Cancer-Associated Fibroblasts in Pancreatic CancerSummary
by: Ralph Francescone, et al.
Published: (2024-01-01)