DNA methylation and bronchiectasis: a Mendelian randomization analysis to investigate causal link and therapeutic target

This study aims to discover drug targeted genes and explore the potential epigenetics mechanisms in bronchiectasis. Cis-expression quantitative trait locus (eQTL) was obtained as exposure, and bronchiectasis from the FinnGen cohort was used as outcome. Mendelian Randomization (MR) was performed to i...

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Bibliographic Details

Published in:	Epigenetics
Main Authors:	Jiangyue Qin, Bi Ran, Lian Liu, Ping Li, Zhenni Chen, Diandian Li, Yongchun Shen, Fuqiang Wen
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Bronchiectasis DNA methylation Mendelian randomization druggable genes VRK2
Online Access:	https://www.tandfonline.com/doi/10.1080/15592294.2025.2521622