ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA

Abstract Background Liquid biopsies and the dynamic tracking of somatic mutations within circulating tumour DNA (ctDNA) can provide insight into the dynamics of cancer evolution and the intra-tumour heterogeneity that fuels treatment resistance. However, identifying and tracking dynamic changes in s...

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Bibliographic Details

Published in:	Genome Medicine
Main Authors:	Ariana Huebner, James R. M. Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A. Toledo
Format:	Article
Language:	English
Published:	BMC 2023-04-01
Subjects:	Pancreatic cancer Tumour evolution Intra-tumour heterogeneity ctDNA Copy number cfDNA
Online Access:	https://doi.org/10.1186/s13073-023-01171-w