Rational design of antibodies with pH-dependent antigen-binding properties using structural insights from broadly neutralizing antibodies against α-neurotoxins

Antibodies that bind in a pH-dependent manner to their antigens show promise for enhanced neutralization potency and blocking capacity against extracellular targets. However, because the mechanisms governing pH-dependent antigen binding remain poorly understood, engineering approaches are often limi...

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التفاصيل البيبلوغرافية

الحاوية / القاعدة:	mAbs
المؤلفون الرئيسيون:	Jack Wade, Nina Štrancar, Monica L. Fernández-Quintero, Suzana Siebenhaar, Tom Jansen, Edward P. W. Meier, Timothy P. Jenkins, Sara P. Bjørn, Giang T. T. Nguyen, Bruno Lomonte, José Maria Gutiérrez, Christoffer V. Sørensen, Johannes R. Loeffler, Arijit Paul, Tulika Tulika, Johnny Arnsdorf, Sanne Schoffelen, Emil V. S. Lundquist, Jennifer Sørensen, Andrew B. Ward, Bjørn G. Voldborg, Markus-Frederik Bohn, Esperanza Rivera-de-Torre, J. Preben Morth, Andreas H. Laustsen
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Taylor & Francis Group 2025-12-01
الموضوعات:	pH-dependent antigen binding acid-switched antibodies snakebite monoclonal antibodies phage display snake venom
الوصول للمادة أونلاين:	https://www.tandfonline.com/doi/10.1080/19420862.2025.2553624