Increased ATP release and CD73-mediated adenosine A2A receptor activation mediate convulsion-associated neuronal damage and hippocampal dysfunction

Extracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A2AR). Convulsive activity leads to increased...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Elisabete Augusto, Francisco Q. Gonçalves, Joana E. Real, Henrique B. Silva, Daniela Pochmann, Tiago S. Silva, Marco Matos, Nélio Gonçalves, Ângelo R. Tomé, Jiang-Fan Chen, Paula M. Canas, Rodrigo A. Cunha
Format:	Article
Language:	English
Published:	Elsevier 2021-09-01
Subjects:	ATP P2 receptors CD73 Ecto-nucleotidases A2A receptors Epilepsy
Online Access:	http://www.sciencedirect.com/science/article/pii/S096999612100190X