Identification and Analysis of Small Molecule Inhibitors of CRISPR-Cas9 in Human Cells

Genome editing tools based on CRISPR–Cas systems can repair genetic mutations in situ; however, off-target effects and DNA damage lesions that result from genome editing remain major roadblocks to its full clinical implementation. Protein and chemical inhibitors of CRISPR–Cas systems may reduce off-...

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書誌詳細

出版年:	Cells
主要な著者:	Yue Yang, Donghua Li, Fen Wan, Bohong Chen, Guanglan Wu, Feng Li, Yanliang Ren, Puping Liang, Jian Wan, Zhou Songyang
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2022-11-01
主題:	CRISPR gene-editing small molecule inhibitor SpCas9 off-target
オンライン･アクセス:	https://www.mdpi.com/2073-4409/11/22/3574