A PAS-targeting hERG1 activator reduces arrhythmic events in Jervell and Lange-Nielsen syndrome patient-derived hiPSC-CMs

The hERG1 potassium channel conducts the cardiac repolarizing current, IKr. hERG1 has emerged as a therapeutic target for cardiac diseases marked by prolonged action potential duration (APD). Unfortunately, many hERG1 activators display off-target and proarrhythmic effects that limit their therapeut...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Chiamaka U. Ukachukwu, Eric N. Jimenez-Vazquez, Shreya Salwi, Matthew Goodrich, Francisco G. Sanchez-Conde, Kate M. Orland, Abhilasha Jain, Lee L. Eckhardt, Timothy J. Kamp, David K. Jones
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2025-02-01
Subjects:	Cardiology
Online Access:	https://doi.org/10.1172/jci.insight.183444