Recombinant thrombomodulin and recombinant antithrombin attenuate pulmonary endothelial glycocalyx degradation and neutrophil extracellular trap formation in ventilator-induced lung injury in the context of endotoxemia

Abstract Background Vascular endothelial damage is involved in the development and exacerbation of ventilator-induced lung injury (VILI). Pulmonary endothelial glycocalyx and neutrophil extracellular traps (NETs) are endothelial protective and damaging factors, respectively; however, their dynamics...

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Bibliographic Details

Published in:	Respiratory Research
Main Authors:	Kenichiro Kikuchi, Satoshi Kazuma, Michiaki Yamakage
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	Biotrauma Glycocalyx Neutrophil extracellular traps Recombinant antithrombin Recombinant thrombomodulin Ventilator-induced lung injury
Online Access:	https://doi.org/10.1186/s12931-024-02958-0