HGA Triggers SAA Aggregation and Accelerates Fibril Formation in the C20/A4 Alkaptonuria Cell Model

Alkaptonuria (AKU) is a rare autosomal recessive metabolic disorder caused by mutations in the homogentisate 1,2-dioxygenase (HGD) gene, leading to the accumulation of homogentisic acid (HGA), causing severe inflammatory conditions. Recently, the presence of serum amyloid A (SAA) has been reported i...

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Bibliographic Details

Published in:	Cells
Main Authors:	Pierfrancesco Mastroeni, Alfonso Trezza, Michela Geminiani, Luisa Frusciante, Anna Visibelli, Annalisa Santucci
Format:	Article
Language:	English
Published:	MDPI AG 2024-09-01
Subjects:	alkaptonuria secondary amyloidosis amyloid metabolic disease serum amyloid A serum amyloid P
Online Access:	https://www.mdpi.com/2073-4409/13/17/1501