Identification and structural characterization of small molecule inhibitors of PINK1

Abstract Mutations in PINK1 and Parkin cause early-onset Parkinson’s Disease (PD). PINK1 is a kinase which functions as a mitochondrial damage sensor and initiates mitochondrial quality control by accumulating on the damaged organelle. There, it phosphorylates ubiquitin, which in turn recruits and a...

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Bibliographic Details

Published in:	Scientific Reports
Main Authors:	Shafqat Rasool, Tara Shomali, Luc Truong, Nathalie Croteau, Simon Veyron, Bernardo A. Bustillos, Wolfdieter Springer, Fabienne C. Fiesel, Jean-François Trempe
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-04-01
Subjects:	PTEN‐induced kinase 1 (PINK1) Kinase Inhibitor Parkinson disease Ubiquitin Mitochondria
Online Access:	https://doi.org/10.1038/s41598-024-58285-3