Autoreactive CD8 T cells in NOD mice exhibit phenotypic heterogeneity but restricted TCR gene usage

Paired scRNA-seq and scTCR-seq reveals that diabetogenic CD8 T cells in the islets and spleens of NOD mice exhibit phenotypic and clonal heterogeneity despite restricted TCR gene usage. Expression of certain TCR genes correlates with clonal proliferation and effector phenotype. Type 1 diabetes (T1D)...

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Bibliographic Details

Published in:	Life Science Alliance
Main Authors:	Moujtaba Y Kasmani, Ashley E Ciecko, Ashley K Brown, Galina Petrova, Jack Gorski, Yi-Guang Chen, Weiguo Cui
Format:	Article
Language:	English
Published:	Life Science Alliance LLC 2022-10-01
Online Access:	https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201503