The role of cytokine licensing in shaping the therapeutic potential of wharton’s jelly MSCs: metabolic shift towards immunomodulation at the expense of differentiation

Abstract Background Cytokine licensing with pro-inflammatory molecules, such as tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ), has emerged as a promising strategy to enhance the therapeutic potential of multipotent mesenchymal stromal cells (MSCs). While licensing has demonstrate...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Olena Rogulska, Eliska Vavrinova, Irena Vackova, Jarmila Havelkova, Klara Gotvaldova, Pavel Abaffy, Sarka Kubinova, Michal Sima, Pavel Rossner, Lucie Bacakova, Pavla Jendelova, Katarina Smolkova, Yuriy Petrenko
Format:	Article
Language:	English
Published:	BMC 2025-04-01
Subjects:	Multipotent mesenchymal stromal cells Wharton’s jelly Cytokine priming Transcriptomics Metabolomics Adipogenic and osteogenic differentiation
Online Access:	https://doi.org/10.1186/s13287-025-04309-2