Poor prognostic factors of pharmacokinetic origin predict outcomes in inflammatory bowel disease patients treated with anti-tumor necrosis factor-α

IntroductionWe evaluated baseline Clearance of anti-tumor necrosis factors and human leukocyte antigen variant (HLA DQA1*05) in combination as poor prognostic factors (PPF) of pharmacokinetic (PK) origin impacting immune response (formation of antidrug antibodies) and disease control of inflammatory...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Elizabeth A. Spencer, Marla C. Dubinsky, Michael A. Kamm, Maria Chaparro, Paolo Gionchetti, Fernando Rizzello, Javier P. Gisbert, Emily K. Wright, Julien D. Schulberg, Amy L. Hamilton, Dermot P. B. McGovern, Thierry Dervieux
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-01-01
Subjects:	drug response tumor necrosis factor clearance inflammatory bowel disease pharmacogenetic
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1342477/full