Discovery of novel favipiravir derivatives with improved pharmacokinetic properties as anti-SFTSV agents

Favipiravir is a nucleobase analogue that exhibits antiviral activities against a variety of RNA viruses. Due to the lack of antivirals to combat SFTS, an emerging tickborne epidemic caused by a RNA virus belonging to the Phenuividae family within Bunyavirales, Favipiravir has been put brand new att...

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Bibliographic Details

Published in:	European Journal of Medicinal Chemistry Reports
Main Authors:	Xiaomeng He, Fan Wu, Wei Li, Runze Zhang, Ruiyang Sun, Zhihong Hu, Wu Zhong, Manli Wang
Format:	Article
Language:	English
Published:	Elsevier 2024-12-01
Subjects:	SFTSV Clinical candidate Favipiravir 3-Hydroxy hemiketal derivatives Pharmacokinetics
Online Access:	http://www.sciencedirect.com/science/article/pii/S2772417424000980