Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination

Summary: Medulloblastoma (MB) is a malignant pediatric brain tumor arising in the cerebellum. Although abnormal GABAergic receptor activation has been described in MB, studies have not yet elucidated the contribution of receptor-independent GABA metabolism to MB pathogenesis. We find primary MB tumo...

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書誌詳細

出版年:	Cell Reports
主要な著者:	Vahan Martirosian, Krutika Deshpande, Hao Zhou, Keyue Shen, Kyle Smith, Paul Northcott, Michelle Lin, Vazgen Stepanosyan, Diganta Das, Jan Remsik, Danielle Isakov, Adrienne Boire, Henk De Feyter, Kyle Hurth, Shaobo Li, Joseph Wiemels, Brooke Nakamura, Ling Shao, Camelia Danilov, Thomas Chen, Josh Neman
フォーマット:	論文
言語:	英語
出版事項:	Elsevier 2021-06-01
主題:	medulloblastoma leptomeningeal disease GABA shunt ABAT tumor microenvironment cerebrospinal fluid
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124721006781