The integrated analysis of SIRT family expression, prognostic value, and potential implications in childhood acute lymphoblastic leukemia

BackgroundAcute lymphoblastic leukemia (ALL) is a rapidly progressive hematological malignancy caused by the dysregulated proliferation and abnormal differentiation or differentiation block of lymphoid precursors. The sirtuin family, as a highly conserved class of protein deacetylases dependent on N...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Xusan Xu, Zhendong Wang, Xiaoxia Wang, Wensen Zhang, Zhengqiang Luo, Xiaomei Zheng, Ronghua Pan, Ying Fu, Yajun Wang, Guochun Huang, Riling Chen, Guoda Ma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	childhood acute lymphoblastic leukemia SIRT1 overall survival prognostic factor drug sensitivity
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1685249/full