Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer

Abstract The therapeutic efficacy of metformin in prostate cancer (PCa) appears uncertain based on various clinical trials. Metformin treatment failure may be attributed to the high frequency of transcriptional dysregulation, which leads to drug resistance. However, the underlying mechanism is still...

詳細記述

書誌詳細

出版年:	Signal Transduction and Targeted Therapy
主要な著者:	Jianheng Ye, Shanghua Cai, Yuanfa Feng, Jinchuang Li, Zhiduan Cai, Yulin Deng, Ren Liu, Xuejin Zhu, Jianming Lu, Yangjia Zhuo, Yingke Liang, Jianjiang Xie, Yanqiong Zhang, Huichan He, Zhaodong Han, Zhenyu Jia, Weide Zhong
フォーマット:	論文
言語:	英語
出版事項:	Nature Publishing Group 2023-08-01
オンライン･アクセス:	https://doi.org/10.1038/s41392-023-01516-2