Suppression of hepatic ChREBP⍺-CYP2C50 axis-driven fatty acid oxidation sensitizes mice to diet-induced MASLD/MASH

Objectives: Compromised hepatic fatty acid oxidation (FAO) has been observed in human MASH patients and animal models of MASLD/MASH. It remains poorly understood how and when the hepatic FAO pathway is suppressed during the progression of MASLD towards MASH. Hepatic ChREBP⍺ is a classical lipogenic...

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Bibliographic Details

Published in:	Molecular Metabolism
Main Authors:	Deqiang Zhang, Yuee Zhao, Gary Zhang, Daniel Lank, Sarah Cooke, Sujuan Wang, Alli Nuotio-Antar, Xin Tong, Lei Yin
Format:	Article
Language:	English
Published:	Elsevier 2024-07-01
Subjects:	Lipid metabolism Fatty acid oxidation Metabolic-Associated Steatohepatitis Carbohydrate-response element binding protein (ChREBP)
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877824000887