Biological Role of Pazopanib and Sunitinib Aldehyde Derivatives in Drug-Induced Liver Injury

Tyrosine kinase inhibitors pazopanib and sunitinib are both used to treat advanced renal cell carcinoma but expose patients to an increased risk of hepatotoxicity. We have previously identified two aldehyde derivatives for pazopanib and sunitinib (P-CHO and S-CHO, respectively) in liver microsomes....

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書誌詳細

出版年:	Metabolites
主要な著者:	Maud Maillard, Cécile Arellano, Christelle Vachoux, Christine Chevreau, Nicolas J. Cabaton, Frédéric Pont, Nathalie Saint-Laurent, Thierry Lafont, Etienne Chatelut, Fabienne Thomas
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2022-09-01
主題:	aldehyde hepatotoxicity pazopanib reactive metabolites sunitinib
オンライン･アクセス:	https://www.mdpi.com/2218-1989/12/9/852