The interaction of tPA with NMDAR1 drives neuroinflammation and neurodegeneration in α-synuclein-mediated neurotoxicity

Abstract The thrombolytic protease tissue plasminogen activator (tPA) is expressed in the CNS, where it regulates diverse functions including neuronal plasticity, neuroinflammation, and blood-brain-barrier integrity. However, its role in different brain regions such as the substantia nigra (SN) is l...

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出版年:	Journal of Neuroinflammation
主要な著者:	Daniel Torrente, Enming J. Su, Alí Francisco Citalán-Madrid, Gerald P. Schielke, Daniel Magaoay, Mark Warnock, Tamara Stevenson, Kris Mann, Flavie Lesept, Nathalie Delétage, Manuel Blanc, Erin H. Norris, Denis Vivien, Daniel A. Lawrence
フォーマット:	論文
言語:	英語
出版事項:	BMC 2025-01-01
主題:	tPA α-synuclein Substantia nigra Parkinson’s disease Neuroinflammation Dopaminergic neurons
オンライン･アクセス:	https://doi.org/10.1186/s12974-025-03336-3