Methods for copy number aberration detection from single-cell DNA-sequencing data

Abstract Copy number aberrations (CNAs), which are pathogenic copy number variations (CNVs), play an important role in the initiation and progression of cancer. Single-cell DNA-sequencing (scDNAseq) technologies produce data that is ideal for inferring CNAs. In this review, we review eight methods t...

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Bibliographic Details

Published in:	Genome Biology
Main Authors:	Xian F. Mallory, Mohammadamin Edrisi, Nicholas Navin, Luay Nakhleh
Format:	Article
Language:	English
Published:	BMC 2020-08-01
Subjects:	Tumor evolution Intra-tumor heterogeneity Single-cell DNA sequencing Copy number aberrations
Online Access:	http://link.springer.com/article/10.1186/s13059-020-02119-8