Effects of Nitric Oxide and Reactive Oxygen Species on HIF-1α Stabilization Following Clostridium Difficile Toxin Exposure of the Caco-2 Epithelial Cell Line

Background/Aims: Stabilization of the hypoxia-inducible factor (HIF-1α) is proposed to provide a protective host-response to C. difficile intoxication. Here, we aimed to elucidate whether nitric oxide and/or reactive oxygen species produced during C. difficile toxin exposure could influence HIF-1α s...

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Bibliographic Details

Published in:	Cellular Physiology and Biochemistry
Main Authors:	Joshua Y. Lee, Simon A. Hirota, Louise E. Glover, Glen D. Armstrong, Paul L. Beck, Justin A. MacDonald
Format:	Article
Language:	English
Published:	Cell Physiol Biochem Press GmbH & Co KG 2013-08-01
Subjects:	CDI Epithelial permeability Intestinal inflammation Hypoxia-inducible factor Nitrosylation iNOS
Online Access:	http://www.karger.com/Article/FullText/354448