Development of a Glycosaminoglycan Derived, Selectin Targeting Anti-Adhesive Coating to Treat Endothelial Cell Dysfunction

Endothelial cell (EC) dysfunction is associated with many disease states including deep vein thrombosis (DVT), chronic kidney disease, sepsis and diabetes. Loss of the glycocalyx, a thin glycosaminoglycan (GAG)-rich layer on the EC surface, is a key feature of endothelial dysfunction and increases e...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	James R. Wodicka, Andrea M. Chambers, Gurneet S. Sangha, Craig J. Goergen, Alyssa Panitch
Format:	Article
Language:	English
Published:	MDPI AG 2017-03-01
Subjects:	glycocalyx endothelial cell dysfunction selectin dermatan sulfate deep vein thrombosis
Online Access:	http://www.mdpi.com/1424-8247/10/2/36