Structural and functional insights into metal coordination and substrate recognition of Akkermansia muciniphila sialidase Amuc_1547

Abstract Sialidases in Akkermansia muciniphila are pivotal for mucin degradation, enabling energy acquisition, modulating gut microbiota balance, and influencing host health. However, their structural and functional mechanisms remain poorly characterized. This study resolved the magnesium-bound crys...

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Bibliographic Details

Published in:	Molecular Biomedicine
Main Authors:	Tao Li, XinYue Tang, YiBo Zhu, NingLin Zhao, YingJie Song, Lihui He, XingYu Mou, Chunlei Ge, Zhenpu Chen, Hai Zhang, Xiaoxuan Yao, Xiaoyuan Hu, Jiaxing Cheng, Hong Yao, Rui Bao
Format:	Article
Language:	English
Published:	Springer 2025-04-01
Subjects:	A. muciniphila Sialidase Crystal structure Six-blade β-propeller CBM-like domain
Online Access:	https://doi.org/10.1186/s43556-025-00265-8