Endoplasmic Reticulum Stress: An Emerging Therapeutic Target for Intervertebral Disc Degeneration

Low back pain (LBP) is a global health issue. Intervertebral disc degeneration (IDD) is a major cause of LBP. Although the explicit mechanisms underpinning IDD are unclear, endoplasmic reticulum (ER) stress caused by aberrant unfolded or misfolded proteins may be involved. The accumulation of unfold...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Dong Wang, Xin He, Chao Zheng, Chengzhe Wang, Pandi Peng, Chu Gao, Xiaolong Xu, Yachao Ma, Mei Liu, Liu Yang, Zhuojing Luo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-02-01
Subjects:	low back pain intervertebral disc degeneration endoplasmic reticulum unfolded protein response cellular homeostasis
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.819139/full