A triad of lys12, lys41, arg78 spatial domain, a novel identified heparin binding site on tat protein, facilitates tat-driven cell adhesion.

Tat protein, released by HIV-infected cells, has a battery of important biological effects leading to distinct AIDS-associated pathologies. Cell surface heparan sulfate protoglycans (HSPGs) have been accepted as endogenous Tat receptors, and the Tat basic domain has been identified as the heparin bi...

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Bibliographic Details

Published in:	PLoS ONE
Main Authors:	Jing Ai, Xianliang Xin, Mingyue Zheng, Shuai Wang, Shuying Peng, Jing Li, Limei Wang, Hualiang Jiang, Meiyu Geng
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2008-01-01
Online Access:	http://europepmc.org/articles/PMC3278312?pdf=render