Inducible Knock-Down of the Mineralocorticoid Receptor in Mice Disturbs Regulation of the Renin-Angiotensin-Aldosterone System and Attenuates Heart Failure Induced by Pressure Overload.

Mineralocorticoid receptor (MR) inactivation in mice results in early postnatal lethality. Therefore we generated mice in which MR expression can be silenced during adulthood by administration of doxycycline (Dox). Using a lentiviral approach, we obtained two lines of transgenic mice harboring a con...

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الحاوية / القاعدة:	PLoS ONE
المؤلفون الرئيسيون:	Elena Montes-Cobos, Xiao Li, Henrike J Fischer, André Sasse, Sebastian Kügler, Michael Didié, Karl Toischer, Martin Fassnacht, Ralf Dressel, Holger M Reichardt
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Public Library of Science (PLoS) 2015-01-01
الوصول للمادة أونلاين:	http://europepmc.org/articles/PMC4659617?pdf=render