Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage

Abstract Background Radiation therapy is the standard of care for central nervous system tumours. Despite the success of radiation therapy in reducing tumour mass, irradiation (IR)-induced vasculopathies and neuroinflammation contribute to late-delayed complications, neurodegeneration, and premature...

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Bibliographic Details

Published in:	Stem Cell Research & Therapy
Main Authors:	Kshama Gupta, Ralph B. Perkerson, Tammee M. Parsons, Ramacharan Angom, Danilyn Amerna, Jeremy D. Burgess, Yingxue Ren, Pamela J. McLean, Debabrata Mukhopadhyay, Prasanna Vibhute, Zbigniew K. Wszolek, Abba C. Zubair, Alfredo Quiñones-Hinojosa, Takahisa Kanekiyo
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	iPSC-MSC Radiation therapy Angiogenesis Inflammation Secretome Biotherapeutics
Online Access:	https://doi.org/10.1186/s13287-024-03847-5