Doxorubicin-sensitive and -resistant colorectal cancer spheroid models: assessing tumor microenvironment features for therapeutic modulation

Introduction: The research on tumor microenvironment (TME) has recently been gaining attention due to its important role in tumor growth, progression, and response to therapy. Because of this, the development of three-dimensional cancer models that mimic the interactions in the TME and the tumor str...

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Bibliographic Details

Published in:	Frontiers in Cell and Developmental Biology
Main Authors:	Ruben Valente, Sandra Cordeiro, André Luz, Maria C. Melo, Catarina Roma Rodrigues, Pedro V. Baptista, Alexandra R. Fernandes
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-12-01
Subjects:	colorectal cancer tumor microenvironment heterotypic spheroid models extracellular vesicles chemoresistance doxorubicin
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2023.1310397/full