Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms

Osteoarthritis (OA) affects multiple tissues of the synovial joint and is characterised by articular cartilage degeneration and bone remodelling. Interferon-γ (IFN-γ) is implicated in osteoarthritis pathology exerting its biological effects via various mechanisms including activation of protein kina...

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Bibliographic Details

Published in:	Biochemistry and Biophysics Reports
Main Authors:	S.J. Gilbert, E.J. Blain, D.J. Mason
Format:	Article
Language:	English
Published:	Elsevier 2022-12-01
Subjects:	Interferon-γ PKR Chondrocyte Osteoblast Inflammation Osteoarthritis
Online Access:	http://www.sciencedirect.com/science/article/pii/S2405580822001236