Role of leucine-rich repeat kinase 2 in severe acute pancreatitis

IntroductionIntrapancreatic activation of trypsinogen caused by alcohol or high-fat intake and the subsequent autodigestion of the pancreas tissues by trypsin are indispensable events in the development of acute pancreatitis. In addition to this trypsin-centered paradigm, recent studies provide evid...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Yasuo Otsuka, Kosuke Minaga, Masatoshi Kudo, Tomohiro Watanabe
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-02-01
Subjects:	leucine-rich repeat kinase 2 (LRRK2) pancreatitis fungi tumor necrosis factor alpha (TNF-α) interleukin 6 (IL-6)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1364839/full