A Conditionally Activated Cytosol-Penetrating Antibody for TME-Dependent Intracellular Cargo Delivery

Currently, therapeutic and diagnostic applications of antibodies are primarily limited to cell surface-exposed and extracellular proteins. However, research has been conducted on cell-penetrating peptides (CPP), as well as cytosol-penetrating antibodies, to overcome these limitations. In this contex...

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Bibliographic Details

Published in:	Antibodies
Main Authors:	Carolin Sophie Dombrowsky, Dominic Happel, Jan Habermann, Sarah Hofmann, Sasi Otmi, Benny Cohen, Harald Kolmar
Format:	Article
Language:	English
Published:	MDPI AG 2024-05-01
Subjects:	cytosol-penetrating antibody cytosolic delivery endosomal escape masked cytosol-penetrating antibody MMP-9 TME
Online Access:	https://www.mdpi.com/2073-4468/13/2/37